NEFAs are a type of lipid that circulates in the blood and is released from adipose tissue (body fat) during periods of fasting or exercise.
NEFAs can be used by the body as an energy source, but high levels of NEFAs in the blood have been associated with insulin resistance, type 2 diabetes, and other metabolic disorders. Elevated levels of NEFAs can contribute to insulin resistance by impairing glucose uptake and utilization in skeletal muscle and liver, as well as by promoting inflammation and oxidative stress.
Monitoring NEFA levels in the blood may be a useful tool for assessing insulin resistance and the risk of developing type 2 diabetes. It's important for individuals with diabetes or at risk of developing diabetes to work closely with their healthcare provider to develop a comprehensive management plan that addresses NEFA levels and other risk factors for the disease.
Publications where this method have been used:
Gaundal L, Myhrstad MCW, Leder L, Byfuglien MG, Gjøvaag T, Rud I, Retterstøl K, Holven KB, Ulven SM, Telle-Hansen VH. Beneficial effect on serum cholesterol levels, but not glycaemic regulation, after replacing SFA with PUFA for 3 d: a randomised crossover trial. Br J Nutr. 2021 Apr 28;125(8):915-925. doi: 10.1017/S0007114520003402.