Neoteryx's Mitra® devices are tools used for microsampling, a technique that allows for the collection of small, precise volumes of biological fluids like blood, urine, or saliva. The Mitra device is designed around the Volumetric Absorptive Microsampling (VAMS®) technology, which facilitates accurate and reliable sample collection that can be easily shipped and stored.
The Mitra device itself resembles a small plastic stick, at the end of which is a small absorbent tip. When this tip is touched to a drop of blood or other fluid, it absorbs a fixed volume of the sample, typically around 10 or 20 microliters, depending on the device. Once the sample is collected, it is left to dry and then can be stored and/or transported for later analysis.
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) can simultaneously analyze 25-hydroxyvitamin D, testosterone, and retinol in blood. Sample preparation involves extracting these analytes and possibly derivatizing them for improved detection. The LC part separates the analytes, while the MS/MS identifies and quantifies them, providing highly sensitive and specific results.
25-OH Vitamin D: This is a test that measures the amount of 25-hydroxyvitamin D, a precursor to the active form of Vitamin D, in the blood. This test is commonly used to assess whether a person is getting enough Vitamin D, either through diet, sunlight, or supplements. Vitamin D is important for bone health because it helps the body absorb calcium. Deficiency can lead to bone diseases like osteoporosis or rickets. Too much Vitamin D, while rare, can also cause health problems.
Testosterone: This is a hormone produced mainly in the testes in men, and in smaller amounts in the ovaries in women. It plays a key role in male sexual development and function but is also important for maintaining muscle bulk, adequate levels of red blood cells, bone growth, and sense of well-being in both sexes. Testing testosterone levels can help diagnose several conditions, such as male infertility, impotence, low sex drive, or other hormonal imbalances.
Retinol (Vitamin A): Retinol is one form of vitamin A, a nutrient needed for vision, the immune system, and reproduction. It also helps the heart, lungs, kidneys, and other organs work properly. A test for retinol in the blood can assess whether a person is getting enough vitamin A. Deficiency can lead to problems like night blindness, dry skin, and increased susceptibility to infections. Excessive intake of Vitamin A can also cause health problems.