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AM-292

Created 08/14/2014 16:53

New application is available from Vitas

AM-292 Arginine, Asymetric and Symetric Dimethyl Arginine (ADMA/SDMA) in plasma, serum and Urine by LC-MS/MS


 

Asymmetric dimethylarginine (ADMA), an analogue of L-arginine, is a naturally occurring product of metabolism found in human circulation. Elevated levels of ADMA inhibit NO synthesis and therefore impair endothelial function and thus promote atherosclerosis. ADMA levels are increased in people with hypercholesterolemia, atherosclerosis, hypertension, chronic heart failure, diabetes mellitus and chronic renal failure. A number of studies have reported ADMA as a novel risk marker of cardiovascular disease.

Vitas AM-292 separates ADMA from SDMA and L-Arginine in serum, plasma and Urine from any species. The method is based on isotope dilution and RP-HPLC MS/MS


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